{"id":373,"date":"2025-09-14T13:02:10","date_gmt":"2025-09-14T13:02:10","guid":{"rendered":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/?p=373"},"modified":"2025-09-14T13:02:10","modified_gmt":"2025-09-14T13:02:10","slug":"une-avancee-majeure-dans-le-traitement-de-la-narcolepsie-grace-a-une-proteine-cerebrale","status":"publish","type":"post","link":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/une-avancee-majeure-dans-le-traitement-de-la-narcolepsie-grace-a-une-proteine-cerebrale\/","title":{"rendered":"Une avanc\u00e9e majeure dans le traitement de la narcolepsie gr\u00e2ce \u00e0 une prot\u00e9ine c\u00e9r\u00e9brale"},"content":{"rendered":"

Des chercheurs du monde entier ont annonc\u00e9 une avanc\u00e9e importante dans le traitement de<\/a> la narcolepsie. Des essais cliniques montrent qu\u2019en stimulant une prot\u00e9ine c\u00e9r\u00e9brale appel\u00e9e orexine-2, on peut aider les patients \u00e0 rester \u00e9veill\u00e9s plus longtemps. Cette prot\u00e9ine joue un r\u00f4le cl\u00e9 dans la r\u00e9gulation de l\u2019\u00e9veil, de l\u2019app\u00e9tit et de l\u2019excitation. Plusieurs laboratoires travaillent sur cette piste, notamment Takeda Pharmaceutical, dont le m\u00e9dicament oveporexton a montr\u00e9 des r\u00e9sultats prometteurs dans des essais de phase avanc\u00e9e. Lors d\u2019un test de maintien de l\u2019\u00e9veil, les participants sous traitement ont pu rester \u00e9veill\u00e9s 20 \u00e0 25 minutes, contre seulement 5 minutes au d\u00e9but de l\u2019\u00e9tude. De plus, les crises de cataplexie (perte soudaine du tonus musculaire) ont diminu\u00e9 de plus de 80 %. Les patients ont \u00e9galement rapport\u00e9 une meilleure qualit\u00e9 de vie, et le m\u00e9dicament a \u00e9t\u00e9 bien tol\u00e9r\u00e9. Takeda pr\u00e9voit de demander son approbation d\u2019ici fin mars. D\u2019autres laboratoires, comme Alkermes et Eisai, travaillent aussi sur des traitements similaires, avec des r\u00e9sultats encourageants. Cette d\u00e9couverte pourrait r\u00e9volutionner la prise en charge de la narcolepsie, une maladie qui touche des milliers de personnes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs du monde entier ont annonc\u00e9 une avanc\u00e9e importante dans le traitement de la narcolepsie. Des essais cliniques montrent […]<\/p>\n","protected":false},"author":1,"featured_media":374,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[414],"tags":[],"class_list":["post-373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles"],"_links":{"self":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts\/373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/comments?post=373"}],"version-history":[{"count":1,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts\/373\/revisions"}],"predecessor-version":[{"id":386,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts\/373\/revisions\/386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/media\/374"}],"wp:attachment":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/media?parent=373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/categories?post=373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/tags?post=373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}