Heidelberg Pharma a rapport\u00e9 des progr\u00e8s encourageants dans son essai de phase 2\/2a du HDP-101, un m\u00e9dicament exp\u00e9rimental pour le my\u00e9lome multiple r\u00e9cidivant ou r\u00e9fractaire. Deux patients dans le groupe 8 ont atteint une r\u00e9mission compl\u00e8te, sans cellules tumorales d\u00e9tectables dans le sang ou la moelle osseuse. Sept patients ont \u00e9t\u00e9 \u00e9valu\u00e9s \u00e0 une dose de 140 \u00b5g\/kg. Tous ont montr\u00e9 un bon profil de s\u00e9curit\u00e9 et de tol\u00e9rance, sans toxicit\u00e9s limit\u00e9es observ\u00e9es. Quatre patients ont montr\u00e9 une activit\u00e9 biologique, y compris une r\u00e9ponse partielle, une tr\u00e8s bonne r\u00e9ponse partielle et deux r\u00e9missions compl\u00e8tes. Le Dr Andr\u00e1s Strassz, directeur m\u00e9dical de Heidelberg Pharma, a d\u00e9clar\u00e9 : “Nous sommes tr\u00e8s satisfaits des donn\u00e9es obtenues jusqu’\u00e0 pr\u00e9sent. Plusieurs patients de diff\u00e9rents groupes ont montr\u00e9 des r\u00e9ponses objectives et une activit\u00e9 anti-tumorale prometteuse. Observer deux r\u00e9missions compl\u00e8tes est une validation encourageante de notre approche th\u00e9rapeutique.” Il a ajout\u00e9 : “Nous avons d\u00e9j\u00e0 vu une r\u00e9mission compl\u00e8te chez un patient du groupe 5, mais dans le groupe 8, l’apparition de la r\u00e9ponse a \u00e9t\u00e9 plus rapide. Ces r\u00e9sultats renforcent notre confiance dans le potentiel th\u00e9rapeutique du HDP-101 chez les patients lourdement pr\u00e9trait\u00e9s atteints de my\u00e9lome multiple r\u00e9cidivant ou r\u00e9fractaire, et nous passons maintenant au groupe 9 avec une dose augment\u00e9e de 175 \u00b5g\/kg pour poursuivre son \u00e9valuation clinique.” L’\u00e9tude de phase 2\/2a est une \u00e9tude non randomis\u00e9e, en ouvert, avec escalade de dose, recrutant des patients atteints de my\u00e9lome multiple r\u00e9cidivant ou r\u00e9fractaire ou d’autres troubles des plasmocytes exprimant le BCMA. Elle vise \u00e0 \u00e9valuer la s\u00e9curit\u00e9, la tol\u00e9rance, la pharmacocin\u00e9tique et l’efficacit\u00e9 pr\u00e9liminaire du HDP-101.<\/p>\n","protected":false},"excerpt":{"rendered":"
Heidelberg Pharma a rapport\u00e9 des progr\u00e8s encourageants dans son essai de phase 2\/2a du HDP-101, un m\u00e9dicament exp\u00e9rimental pour le […]<\/p>\n","protected":false},"author":1,"featured_media":390,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[414],"tags":[],"class_list":["post-389","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles"],"_links":{"self":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts\/389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/comments?post=389"}],"version-history":[{"count":0,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/posts\/389\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/media\/390"}],"wp:attachment":[{"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/media?parent=389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/categories?post=389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imagerie-medicale-95.fr\/pharmacie\/wp-json\/wp\/v2\/tags?post=389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}